Genemed Synthesis Inc.
Genemed Synthesis Inc.
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Friday July 10, 2020
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Home PageOnline Product Catalog > Custom Peptides & Small Molecule

Genemed Synthesis Inc. can synthesize peptide derivatives with p-boronophenylalanine, a phenylalanine structure containing Boron. This molecule is used for Boron neutron capture therapy (BNCT). p-boronophenylalanine is the most successful drug in clinical neutron capture therapy (1); because of the amino acid transport channel called LAT1 that is used by the cells to transport p-boronophenylalanine. LAT1 recognizes the phenylalanine structure which is overexpressed by cancer cells (2,3). The efficiency and efficacy of this method are found to increase if combined with Poly-vinyl alcohol (4). If you want to order a p-boronophenylalanine derivative, please go to our peptide quote request form and send it to us.

Reference:

1.Y. Mishima, C. Honda, M. Ichihashi, H. Obara, J. Hiratsuka, H. Fukuda, H. Karashima, T. Kobayashi, K. Kanda, K. Yoshino, Treatment of malignant-melanoma by single thermal-neutron capture therapy with melanoma-seeking 10B-compound. Lancet 2, 388–389 (1989).
2. A. Wittig, W. A. Sauerwein, J. A. Coderre, Mechanisms of transport of p-borono-phenylalanine through the cell membrane in vitro. Radiat. Res. 153, 173–180 (2000).
3. P. Wongthai, K. Hagiwara, Y. Miyoshi, P. Wiriyasermkul, L. Wei, R. Ohgaki, I. Kato, K. Hamase, S. Nagamori, Y. Kanai, Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2. Cancer Sci. 106, 279–286 (2015).
4. T. Nomoto, Y. Inoue, Y. Yao, M. Suzuki, K. Kanamori, H. Takemoto, M. Matsui, K. Tomoda, N. Nishiyama, Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism. Sci. Adv. 6(4), (2020)

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    showing 1 - 25 of 40   next 15
Catalog# Product Description Product Type Antibody Type Size Price
91-1122
Enzyme/Protein Conjugation: Alkaline Phosphatase Service 1 Contact Sales
91-1123
Enzyme/Protein Conjugation: Horseradish Peroxidase Service 1 Contact Sales
91-1124
Enzyme/Protein Conjugation: BSA Service 1 Contact Sales
91-1125
Enzyme/Protein Conjugation: B-Galactosidase Service 1 Contact Sales
91-1126
Peptide conjugation to KLH (peptide) Service 1 Contact Sales
92-0000
Peptide synthesis (AA) Service 1 Contact Sales
92-1100
Peptide Synthesis of 8-30 residues (price per AA), 15-40mg scale Service 1 Contact Sales
92-1101
Peptide Acetylation Service 1 Contact Sales
92-1102
Peptide Anilide (C-Terminal) Service 1 Contact Sales
92-1103
Peptide Benzyloxcarbonylation Service 1 Contact Sales
92-1104
Peptide Biotinyaltion Service 1 Contact Sales
92-1105
Peptide Dansylation Service 1 Contact Sales
92-1106
Peptide Dinitrobenzoylation (DNP) Service 1 Contact Sales
92-1107
Peptide Fatty acid Service 1 Contact Sales
92-1108
Peptide Formylation Service 1 Contact Sales
92-1109
Peptide Nitronation Service 1 Contact Sales
92-1110
Peptide Phosphorylation-Serine Service 1 Contact Sales
92-1111
Peptide Phosphorylation-Threonine Service 1 Contact Sales
92-1112
Peptide Phosphorylation-Tyrosine Service 1 Contact Sales
92-1113
Peptide Succinylation Service 1 Contact Sales
92-1114
Peptide Sulfonation Service 1 Contact Sales
92-1115
Peptide Aminocoumarin Service 1 Contact Sales
92-1117
Peptide Fluorescean Service 1 Contact Sales
92-1118
Peptide Lissamine Rhodammine Service 1 Contact Sales
92-1119
Peptide NBD Service 1 Contact Sales
    showing 1 - 25 of 40   next 15



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